P24 THE LEVEL OF MICROELEMENTS MG, CU, ZN IN HAIR AND NAILS CHILDREN SUFFERING WITH ALOPECIA TOTALIS/SUBTOTALIS AND ALOPECIA AREATA

¹N.Konstantinova, ¹D.Gaevski. ¹Moscow Medical University, Russia, ²Nioxin Research Inc, USA

Many immune diseases, cancer, etc. are accompanied by the distortion of microelement balance. We study a level of Zn, Mg and Cu in hair and nails of 19 children in the age group from 9 to 14 year old who have suffered with Alopecia Totalis/Subtotalis(AT/S) and Alopecia Areata(AA) for more than 1.5 year.  

The concentration of microelements was measured before and after treatment (tx) in hair and nails using X-ray fluorescent analysis “SPECTROSCAN”, without preliminary chemical treatment, which keeps the samples unchanged for future studies.  

Result: Before treatment in both groups AT/S and AA the level of Zn, Cu in hair and nails was statistically lower in comparison to control group level. The level of Mg was significantly higher than control one. After the use of local treatment Nioxin/Scalp Therapy within 7-9 weeks in AT/S group we noticed the appearance of villous hair in 3, and terminal hair in 8 out 12 children. Zn level increased 8.3 times and almost reached control level, but was statistically different (p<0.0027). Cu increased 6.8 times (p<0.034), Mg decreased. In AA group after 7-9 weeks of Nioxin Therapy 2 pts had villous hair and 3 pts had terminal hair regrowth. Zn and Cu level increase was statistical significant, Mg was insignificantly lower than control level (p<0.057). So in the 1^st AT/S group 8 out of 9 children had hair regrowth and significant improvement of microelement content.

Conclusion: Nioxin topical therapy is an effective and save way to treat AA and AT/S children with minimum negative standard therapy side effects. Miniaturization of hair and interruption of hair cycle is correlated with microelement distortion. In case of AT/S significant improvement in Zn, Cu and Mg was revealed, however, in the case of AA behavior of microelements is more complicated.  Increased level of Zn and Cu and decreased level of Mg may play role in the normalization of hair cycle.