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O#24 Comparative efficacy of oral finasteride and topical 2% minoxidil in male pattern baldness D. Hugh Rushton. School of Pharmacy, University of Portsmouth, Portsmouth, UK Hair variables obtained with the unit area trichogram in
two double blind clinical trials employing topical 2% minoxidil
were compared with values from subjects treated with oral
finasteride (1.25mg.d-1). Thirty male subjects aged 18 and
52 years, with varying degrees of male pattern baldness were
evaluated for total hair density (hair per cm2), useful hair
density (hair longer than 3 cm per cm2) and per cent of hair
in the anagen growth phase and after 12 months treatment with
oral finasteride (n=15) or topical minoxidil (n=15). Compared
to baseline no significant mean change in any hair variable
could be found after 12 months of minoxidil therapy. In contrast,
subjects treated with oral finasteride had an increase in
total hair density (p = 0.06) and a significant increase (p
< 0.01) in the percentage of hair in the anagen growth
phase. Finasteride treated subjects matched for total hair
density had a significant (p < 0.05) increase in useful
hair density, with 53% achieving an increase of more than
15 hairs longer than 3 cm (1 inch) per cm2, compared with
13% using topical minoxidil. After 12 months of treatment
the individual's subjective assessment of their hair found
that 40% of the finasteride group but interestingly and indifferent
to the objective data, 82% of the minoxidil treated group
thought they had more hair compared with baseline. |
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