P#28  Different endocrinological disorders showing androgenic alopecia as a clinical picture

Eniko Telegdy1, Susanne Juricskay2 and Beatrix Farkas1. 1Dept of Dermatology, Faculty of Medicine,University Pècs, Hungary 2Central Research Laboratory, University Pècs, Hungary

Four different cases are described with a variety of hormonal background of androgenic type of alopecia. The patients are women (age 7-57 years). Enzyme hydrolysis, solid phase extraction, methoxym-silyl derivatization and capillary gas chromatographic analysis were used to examine the changes in urinary steroid metabolites (Shackleton, Honour ). By the 7-year-old girl three-four times increased urinary levels of androstandiol, 11-OH-androstendion, tetrahydro-11-deoxycortisol, and tetrahydro-11-dehydrocorticosterone were measured, causing effluvium and hirsutism which was due to the regular topical steroid therapy of her psoriasis. The 16-year-old patient showed a significant elevation of 11a-hydroxylase and 5a-reductase enzyme's metabolites which is observed in polycystic ovarium syndrome, and was proved in this case too. The 57-year-old woman with a history of hypertension showed up to ten-fold increased levels of androsteron, cortisol and their metabolites. These data show hyperadrenal activity, in this case bilateral adrenal adenoma. The 29-year-old woman had no significant differences in the urinary steroid metabolites measurement but elevated serum prolactin level were found leading to the diagnosis of prolactinoma. With this cases we would like to show how to use this method in the differential diagnose of androgenic alopecia.