FC-12   INTEREST OF HAIR DIAMETER DIVERSITY AND PERIPILAR SIGNS DURING THE FOLLOW-UP OF ANDROGENETIC ALOPECIA IN ROUTINE CLINICAL PRACTICE

P. Reygagne, C. Jouanique, C. Deloche*, E. Maréchal, P. Bastien*, A. Bielicki*, O. de Lacharrière*. Centre de Santé Sabouraud, Hôpital Saint Louis1, Paris, *L’Oréal Recherche, Sciences du Vivant Clichy, France.

Recently, we reported that hair diameter diversity (HDD) and peripilar signs (PPS) on the scalp were associated with androgenetic alopecia (AGA). The aim of the present study was to assess the pertinence and interest of these signs during follow-up in routine clinical practice. Three hundred subjects (200 men and 100 women) aged between 18 and 40 years with a clinical diagnosis of AGA were enrolled in this study during their routine consultation with their dermatologist. Patients were prescribed the best adapted treatment by their dermatologist. Six months after the first visit (T0), 119 subjects were re-examined. At each visit macrophotographs were taken on a delineated vertex area of each subject using a Dermaphot® camera. Hair density, mean hair diameter, hair diameter diversity and peripilar signs were scored on photographs scales according to reference scales for each parameter. At the six month visit, patients were asked to self assess the evolution of their hair loss during the last six months and the evolution of the volume of their hair. In the male population self assessed decrease in hair loss was associated with a decrease in HDD and PPS; an increase of the volume of the hair was associated with a decrease of PPS; a decrease of HDD was associated with an increase in hair density. In the female population, a decrease in hair loss was associated with a decrease in HDD and with an increase of hair density scored with our method ; an increase of the volume was associated with a decrease in HDD. These results demonstrate that self assessed efficacy of reference therapies for AGA is associated with changes in HDD and PPS. In addition these signs could be important factors, which could be used by the dermatologists in the follow-up of AGA.