P5.46 THE EFFECT OF COAPPLICATION OF SUBSTANCE P AND CALCITONIN GENE RELATED PEPTIDE ON THE HUMAN HAIR GROWTH IN VITRO

Eunyoung Lee, Soo Young Jeon, Tak Heon Oh, Sanghoon Lee, Won-Soo Lee

Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea

Among constituents of the skin, the hair follicle is the organ where nerve fibers are distributed with the highest density. Recently, it has been reported that neuropeptides, which are secreted by nerve fibers, have important roles in hair growth and cycling. In addition, the expression of various growth factors and apoptosis-related molecules are important in hair growth and cycling. Therefore, it is thought that the analysis of the relationship between neuropeptides and the expression of various growth factors at the level of the hair follicle and hair follicle cells is important. In this study, we examined the effect of the coapplication of substance P(SP) and calcitonin gene related peptide(CGRP) on human hair growth in vitro. We detected mRNAs corresponding to FGF-7, IGF-1, VEGF, IL-1α, IL-1β, p53, and caspase-3. Results: In hair organ culture, the expression of caspase-3 and IL-1β was increased compared to the control, while in dermal papilla cell culture, the expression of IL-1β was increased compared to the control.