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P8.89 THE KÖBNER PHENOMENON IN TRICHOLOGY d’Ovidio R*, Claudatus J° and Di Prima T^ AIDA-Tricologia, °Clinica S.Rita-Bari,*Università di Catania-Italy The Köbner phenomenon (KP) was first described in patients with active psoriasis; since then the term of KP or “reactive isomorphism” has been utilized by dermatologists in several cases where the underlying disease “emerges” after trauma (traumatic injuries to the skin). Objectives: In our presentation, the clinical evidence of KP in some hair diseases will be described. We report on cases of Lichen Planus- Pilaris, Pseudoarea of Brocq and Lupus Erythematosus of the scalp which were exacerbated by spontaneous or iatrogenic trauma, and describe our experience of cases with KP and its variants, such as “inverse-KP” and “Rembök-phenomenon” in Alopecia Areata. Conclusions: Considering the possible role of mast cells as triggers of KP in psoriasis, their implication in the cases described will be suggested on the basis of histological evidence. The possible involvement of neuromediators like substance P in the pathogenesis of KP through mast cell activation will also be discussed, thus underlining the importance of “psycho-“ or “neurogenic” stress as a potential trigger factor in various clinical forms of alopecia.Finally, we believe that the identification of this phenomenon may explain why some treatments are ineffective or even exaccerbate the clinical picture when utilized in the active phase of the disease -even in the same patients where this therapy had been previously efficacious. |
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