P9.118 DOES AMINEXIL PREVENT HAIR LOSS IN PATIENTS WITH ANDROGENETIC ALOPECIA WHO STOP FINASTERIDE TREATMENT?

Colombina Vincenzi, Alfredo Rossi*,Carmen Cantisani*, Massimiliano Pazzaglia, Antonella Tosti

Department of Dermatology, University of Bologna, Italy, * Department of Dermatology , University La Sapienza, Rome, Italy

The aim of this study was to evaluate whether topical treatment with Aminexil lotion would prevent or reduce hair loss which usually occurs after discontinuation of oral finasteride treatment.

The study involved 18 male patients aged from 20 to 43 years (median age 30.03) affected by androgenetic alopecia (Hamilton/Norwood classification scale IIv – IV) who had been successfully treated with finasteride 1 mg for at least 1 year. All these patients had decided to stop finasteride intake because of side effects or personal reasons. They all applied Aminexil lotion once daily for one year until completion of the study. Assessment was carried out using hair counts (obtained from color macrophotograph of an area 2,2 cm2 in diameter) and standardized global photograph of the anterior/mid region of the scalp taken at the baseline (phase 0), after 6 months (phase 1) and at the end of the study (phase 2). After 1 year of Aminexil treatment, the mean hair count decreased by 30 ± 44 hairs. However an increase in hair count was found in 3 patients. Evaluation from global photographs showed a moderate decrease in 3 patients, a slight decrease in 6 patients and no changes in the remaining 9 patients.

The present study suggests that Aminexil may be helpful in preventing hair loss after stopping finasteride treatment. Further studies on a large number of patients are needed to confirm these preliminary results.