P24 ELECTRONOOPTIC MODIFICATION OF THE HAIR SHAFT AND SULPHUR CONTENT OF THE HAIR AND NAIL IN A CASE OF TRICHOTHIODYSTROPHY ASSOCIATED WITH HYPEREOSINOPHILIC SYNDROME
Solovan C, Feier V
University of Medicine and Pharmacy 'Victor Babes' Department of Dermatology, Timisoara, Romania

We present a female case of 47 years old, in our observation for 30 years for Trichothiodystrophy (TTD) associated with hypereosinophilic syndrome. We noticed a non-scaring alopecia of the vertex (with unequal, fragile, brittle, sparse hair), axillary and pubic region as well as koilonychia of the fingernails. Along with other investigations, the hair shaft showed in scanning electronoptic microscopy the presence of a cuticle covered by flat cells and a longitudinal depression. Polarized light examination showed bright and dark zones with "tiger tail " aspect. The hairs were analyzed by "Energy Dispersive X-ray Analysis" which showed a low Sulphur (S) content. This was confirmed by X-ray diffraction, which evidenced low S=6,12 (normal=6,52). We also examined the nails by X-ray diffraction which showed lower value of S=2,17 (normal=3,31) too. The S content of hair and nail varies between very strict limits in our observation.