P41 NOT ONLY A SURGICAL APPROACH IN HAIR TRANSPLANT
Rinaldi F, Bezzola P, Sorbellini E
Rinaldi Dermatological Center, Milan, Italy

What happens to each hair follicle during and after a hair transplant? How many developmental pathways share with it? The mature hair follicle is a "miniorgan" with a complex regulated growth cycle, and we must consider all the influences (tissue regeneration, stem cell activation, re-vascularization, hormone responsiveness) on the bulb structures (dermal papilla, matrix, root sheats, stem cells of the bulge) and on the treated skin. This is why it could be important, for the best result of a hair transplant, to evaluate all the biological risks of the bulb during the transplant phase and in the next period, the hormone influences (androgens, estrogens, vitamin D receptors, IGF-1 and insulin resistance) and to try to prevent their consequences. The process of hair growth utilizes many cellular and molecular mechanisms common to angiogenesis and wound healing. It is possible, today, to use some specific substances (proline rich polypeptide, thymosine beta4, specific aminoacidic pool with proline, valine, leucine, taurine and ornythine) to control neo-angiogenesis in the transplanted skin and wound healing, to stimulate stem cell migration, protease production, cell differentiation. We studied the effect of a pool of specific aminoacids per os on the transplanted hair, to evaluate the biological and medical possibility to control these mechanisms, and to improve the result of a hair transplant.